This is really a job better suited to a compositor program like Aftereffects, combustion, shake, etc. but yes you can do it in photoshop.
Export the clip as a sequence of targa or tiff stills, uncompressed, all in one folder.
Open that folder in photoshop, open the first image and use the healing brush, not the clone stamp, to remove the blemish. Save the image.
Repeat for the next 2000 frames, or however long the clip is. RE-import the folder of frames, first making sure your bin settings are set for single-frame duration of imported stills, and make this bin separate from the rest. Select>all, drag and drop back onto the video track for a perfect fit.
That "repeat for 2000 frames" part is why a compositor program like AE or Combustion is a better choice; you only have to manually clean a certain number of key frames, but it would do all the other frames in-between for you.
But if the scene doesn't have a lot of movement, what you can do as a cheat, and maybe get away with, is manually do just the first frame, while recording it as a batch action. Then you can apply that batch action to the whole folder's worth of still images automatically. The last time I did this, after manually rotoscoping each frame of a commercial for two days, well, the batch action did the same job and more consistently in about 15 SECONDS.
So read up in the user manuals how to record and apply batch actions in photoshop. They are powerful juju.
Another way to go is to use the color correction/color replacement capability in either photoshop or your NLE editing system to select just the color of the pimple, and tell it to *replace* that pimple color with a sample of clean flesh tone from right next to the blemish. Think of it as chroma-keying the red blemish as if it were green screen, and replacing it with flesh color. This color replacement technique will require a bit of masking and possibly layering two identical tracks of the video on your timeline, with a soft-edged matte mask cutting thru one original layer to the other, treated layer. The setup time for this effect takes the most time, but once applied, it's done instantly thruout the clip.
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